Monthly Archives: September 2014

MTHFR Genetic Mutations and Epstein Barr Virus

It’s been a long time since my last post.  I’ve struggled with convincing my current functional doctor to move on and start testing for other things because I’ve been doing all his protocols for the last four months and still am not feeling better.  Finally got tested through Labcorp for MTHFR gene mutations and Epstein Barr, which I tested positive for both.  I also tested for lyme disease, rheumatoid arthritis, and anti-nuclear antibodies, which were all negative.

So, a little about MTHFR mutations.  Methylenetetrahydrofolate (MTHFR) is a key enzyme in the folate pathway and is responsible for the metabolism of homosysteine.  There are two common mutations, C677T and A1298C.  I have both.  If you have just one you can still function, methylate folate, at 70%, but when you have both mutations, it cuts it down to 20%, which is more difficult to deal with.  This could very well explain my exhaustion but add to that a raging case of Epstein Barr Virus (positive is anything greater than 21.9, mine was 600) and I’m one pooped puppy. 

Next step with my doctor is for me to take three different products containing methylate folate as well as other supportive supplements.  I started doing research and decided this might not be the best thing to do, see http://MTHFR.NET/.  I went to a nurse that I’m seeing here in Durango and asked her if she was experienced in dealing with MTHFR, she recommended another clinic here who deals specifically with this.  They have three naturopath doctors and a biochemist on staff.  He said it could be detrimental to treat without checking first for other genetic mutations.  He asked that I order a 23andme kit for $99 which he can take the data and interpret for me.  This is also what the MTHFR. NET site recommends.  So, I sent my kit in today and will wait 4 weeks or so for the results. 

I’m hanging in there but realize now more than ever that controlling my stress response and not letting things get to me is more important than ever.  I love this quote from a Six Feet Under episode, “Why are you hanging onto your pain like it means something, it doesn’t mean shi*t.  Let it go.”  Find things to be grateful for and on the bad days just realize it won’t always be that way.  Much love!